What is the relationship between serum uric acid levels and Alzheimer’s disease risk, supported by cohort studies, and how do high uric acid patients compare with low uric acid patients?

Hello, this is Mr. Hotsia.

I am 56 years old. I’m writing this from my home in Chiang Rai, in northern Thailand. For 30 of those 56 years, my “job” was to be on the road. My life’s work, as you might know from my YouTube channels ¹, was to travel to every single province of Thailand, Laos, Cambodia, Vietnam, and Myanmar².

My “research method” was living. I ate with the locals. I saw the “ground truth.”

And in 30 years, I’ve seen two different worlds of “aging.”

The “Old Way” (30 years ago): I sat with 70-year-old grandmothers in remote Lao villages. They were poor (low-income). They were thin. They were strong. They worked (movement) in the fields all day. Their “food” was “real”—rice, fresh fish, mountains of herbs. Their “system” was clean. Their “mind” was sharp.

The “New Sickness” (Today): I sit in that same village, and the granddaughter is different. She’s overweight. She’s sedentary. Her “food” is “new” (instant noodles, sugary sodas). Her “sickness” is also “new”: diabetes, high blood pressure.

And Gout (the “rich man’s sickness” that is now “cheap”).

And her “mind” is foggy.

Now, I live a second life. I’m a systems analyst by training333. Since I retired from government service, I’ve built a career as a professional digital marketer. It’s a job that earned me a ClickBank Platinum Award in 20224.

My new “job” is to sit.

My new “job” is to analyze data. I run over 40 websites5, and I research the “high intent keywords” of a US audience. I see what they fear.

And the fear I see in the data is explosive:

“gout and brain fog.”

“gout and memory loss.”

“uric acid and alzheimer’s.”

My “ground truth” (the sharp grandmother) and my “data” (the fear of the “fog”) have collided.

This is a systems failure.

As a systems analyst, I had to understand why.

A “patch” (a pill) is “bailing water.”

The real “sickness” is not the “gout.” The gout is the “symptom.”

The real “sickness” is the “System” that causes the “gout.”

Here is my deep-dive analysis.

😵 The “System Failure” (The “Paradox” of the “Rust”)

First, my “systems analyst” brain.

We must understand the system failure.

“Gout” and “Alzheimer’s” (AD) are not “friends.”

They are supposed to be enemies.

“System 1” (Gout):

The “Problem”: Too much “waste.”
The “Failure”: The “engine” (liver) makes “waste” (Uric Acid) from “dirty fuel” (purines – in my Kaphrao Sajai with meat⁶, in beer). The “filter” (kidney) “fails.” The “system” is flooded with “waste.”
The “Scream”: The “waste” (Uric Acid) turns into “needles” (crystals) in the “hardware” (the joint).

“System 2” (Alzheimer’s):

The “Problem”: “Engine” (brain) failure.
The “Failure”: The “engine” (brain) fails. The “wiring” (nerves) “dies.”
The “Cause” (The Data): Why? It is attacked by “Rust” (Oxidative Stress).

Now… the “Paradox.”

My “data” research (for my ClickBank work) shows this:

Uric Acid (the “waste” that causes “Gout”) is the body’s most powerful “Anti-Rust Spray” (Antioxidant) in the blood.

This is the “systems analysis.”

Gout = High “Anti-Rust Spray” (Uric Acid).
Alzheimer’s = High “Rust” (Oxidative Stress).

Therefore… the “systems” are enemies. The “sickness” (Gout) should “fix” (prevent) the other “sickness” (AD).

This is what “scientists” (the “data analysts”) believed for 20 years.

They saw this in the “data” (the cohort studies).

🔥 The “Ground Truth” (The “Fire” That Causes “Both”)

This is the “systems failure.” The “old logic” is wrong.

The “Lao grandmother” (my “ground truth”) proves this.

She has no “fire”. She has low “waste”. She has a sharp “mind”.

The “new sickness” (the granddaughter) proves the new “data”.

The “new data” (the neuroinflammation research) is the “ground truth.”

The problem is not the “waste” (UA).

The problem is the “New Sickness” (Metabolic Syndrome, my granddaughter’s “sickness”).

The “new sickness” (processed food, sugar, stress—my “Hanoi traffic jam” ground truth) is the “Fire” (Systemic Inflammation).

This “fire” is the “accelerant.”

The “Fire” causes the “Gout”: The “fire” (inflammation) “breaks” the “engine” (metabolism). The “engine” panics and makes too much “waste” (uric acid).
The “Fire” causes the “Dementia”: The same “fire” (inflammation) crosses the “plumbing” (the blood-brain barrier). This is Neuroinflammation.
The “Fire” is the “Rust”: This “fire” is the Oxidative Stress (the “rust”) that “breaks” the “engine” (the brain).

This is the systems failure.

It is not “Gout causes Dementia.”

It is: The “Fire” (Inflammation) causes “Gout” AND “Dementia.”

It is one “cause” (the “new sickness”) creating two “symptoms”.

📉 The “Outcomes” (High vs. Low UA Patients)

This is the core of the “systems analysis.” How do they compare?

This is the “trap” of the “old data.”

1. The “High UA” (Gout) Patient (The “Old Data” Hero)

The “Old Logic”: This “system” is “safe.” It is “protected” by the high “anti-rust spray”.
My “Systems Analysis” (The Failure): This is wrong.
1. The “anti-rust” (UA) is in the plumbing (blood). It cannot “fix” the “engine” (brain).
2. The cause (the “Fire”) is raging.
The “Outcome”: The “engine” (brain) is “rusting” (Neuroinflammation). The “outcome” is High Risk.

2. The “Low UA” Patient (The “Old Data” Victim)

The “Old Logic”: This “system” is “failing.” It has no “anti-rust spray”.
My “Systems Analysis” (The Failure): This is also “wrong.”
- “System A” (The “Lao Grandmother”): Low UA because the “system” is clean. No “Fire.” The “engine” (brain) makes its own “anti-rust” (Glutathione). Outcome = Low Risk.
- “System B” (The Granddaughter): Low UA… but… the “Fire” (the “new sickness”) is raging.
- The “Outcome”: The “fire” is still “rusting” the “engine” (brain). The “outcome” is High Risk.

The “UA level” (the “data”) is irrelevant.

The “Fire” (the Lifestyle) is the only “data” that matters.

📊 Table 1: Mr. Hotsia’s “Systems Log” (The “Failure” Comparison)

As a systems analyst, I log the data.

The “System” (The Patient)	The “Fuel” (The “Fire”)	The “Waste” (UA)	My “Hotsia” Verdict (The “AD” Risk)
“Lao Grandmother” (Old Way)	Clean (No “Fire”)	Low	Low. (The “engine” is clean).
Gout Patient (New Sickness)	Dirty (High “Fire”)	High	High. (The “engine” is on fire).
“Foggy” Granddaughter (New Sickness)	Dirty (High “Fire”)	Low	High. (The “engine” is still on fire).

📊 Table 2: The “Outcomes” Analysis (The “Fix”)

Here is my “field guide” as both a traveler and an analyst. This is how they “compare.”

The “Problem”	The “No Intervention” Fix (Failure)	The “ULT” Fix (The “Patch”)	The “Old Way” Fix (The “System”)
*Gout (The Symptom)*	Catastrophic.	Good. (The “patch” works).	Good. (The “fix” works).
*Dementia (The Fog)*	Catastrophic.	Failure. (The “patch” ignores the cause).	The “Fix.” (It fixes the cause).
*The “Fire” (The Cause)*	Catastrophic.	Failure. (It ignores the “fire”).	The “Fix.” (This is the “target”).
The “Ground Truth” (QoL)	Low. (Pain and “fog”).	Low. (No “pain,” still “fog”).	High. (The “system” is clean).

🌏 A Traveler’s Final Word: The “System” is the “Ground Truth”

I am 56 years old. I must keep moving (my travels). But my new job (my ClickBank work) forces me to sit.

My body is “ground zero” for this “systems failure.”

My “ground truth” (the sharp grandmother) and my “data” (the studies) are the same.

The “data” is undeniable:

The “patch” (pills) loses. It is a temporary “fix” for a symptom.
The “system” (lifestyle) wins. It is a lasting “fix” for the cause.

The “new sickness” (a sedentary, high-stress, processed-food life) breaks the “system.”

The “old way” (the movement, the real food [like my Kaphrao Sajai, cite: 19], the calm) is the only “fix.”

You must fix the “system,” not just “patch” the “symptom.”

You must “clean the fuel” and “stop the fire.”

🙋‍♂️ My Research FAQ (Frequently Asked Questions)

1. Is it gout causing dementia?

My “systems analyst” answer: No. This is the key. It is a “systems failure.” The “Fire” (Inflammation) causes the “Gout” AND the “Dementia.”

2. But isn’t Uric Acid good for the brain? (The “Paradox”).

My “ground truth” answer: Yes. The “anti-rust” (Uric Acid) is “good.” But the cause (the “fire”) is the “enemy.” It’s a “broken system.” You cannot “fix” the “fire” by “ignoring” it.

3. Will my “gout pill” (Allopurinol) “fix” my “fog”?

My “data” answer: No. The “data” is clear. It “patches” the “waste” (uric acid). It does not “patch” the “fire” (the inflammation). The “fire” is the “fog.”

4. What about the “old way” (the Lao grandmother)?

My “ground truth” answer: She is the “fix.” Her “system” was “clean.” Her “food” was the “fix.” Her life (movement) was the “fix.” The “new sickness” (sitting) is the “disease.”

5. Mr. Hotsia, what’s your “fix”?

My “ground truth”? I’m 56. My “systems” (travel and sitting) are both “stress.”

I eat the “old way” (my Kaphrao Sajai – which has herbs).
I move (my travels).
I respect the “data” (the studies)… and the “data” proves the “old way” (the clean fuel) is the “smarter system.”

I’m Mr.Hotsia, sharing 30 years of travel experiences with readers worldwide. This review is based on my personal journey and what I’ve learned along the way. Learn more